Regular exercise improves cardiometabolic health and reduces risk for chronic disease. There are few 

long-term adaptations to exercise that persist in the absence of a continued exercise stimulus (use it or 

lose it). The "trained" state is maintained only with regular applications of individual exercise bouts.  Each 

individual exercise bout is appropriately viewed as a drug, meaning; when taken at a sufficient dose, about 

of exercise has effects on metabolic health that peak at a specific timepoint and then diminish over time until 

they are no longer apparent, requiring a subsequent "dose" to maintain the beneficial effects.

Viewed in this context, each individual dose of exercise is important.  Tailoring the intensity, duration, 

nutritional environment and interactions with other medications to achieve the maximal benefit will likely have 

the most effective impact on metabolic health.

To optimally use exercise to minimize insulin resistance and prevent/manage Type-2 diabetes, we hope to:

1.  Better understand the mechanism by which exercise benefits metabolic health

2.  Work out the dose-response relationship between the intensity/duration/frequency of exercise and the 

benefits to metabolic health

3.  Learn how exercise interacts with energy balance, dietary nutrients, and pharmacologic agents that also 

impact metabolic health.