UMASS Amherst: Energy Metabolism Laboratory

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Insulin Resistance/Type 2 diabetes and Sex Hormones and Substrate Use during Exercise.

Click here for a brief power point presentation of recent studies and findings. Click HERE for a not so brief presentation that highlights all of the recent work in the lab and how it relates to optimizing the use of exercise to oppose insulin resistance and potentially prevent/manage Type-2 diabetes.

Publications related to insulin resistance and/or type 2 diabetes:

Recent publications and those in review:

-Braun B., Hagobian TA, Sharoff CS, Stephens BR, Eza P.  The effect of metformin treatment on maximal oxygen consumption. Appl. Phys. Nutr. Metab. in press, 2008

-Stephens BR, Sharoff CG, Chipkin SR, and Braun B.  The effect of post-exercise meal timing on insulin action. Appl. Physiol. Nutr. Metab.  in press, 2007

-Black S and Braun B. Influence of short-term training on substrate kinetics and utilization during exercise in women.

-Sharoff CG, Stephens BR, Hagobian TA, Chipkin SR, Braun B.  Effects of galactose consumption prior to exercise on blood glucose regulation in individuals with Type 2 diabetes.

Tittles of current thesis/dissertation projects:

-C. Sharoff (Dissertation): The role of AMPK in mediating post-exercise improvements in insulin action.

-T. Hagobian (Dissertation): Effects of energy deficit on the neuroendocrine response to exercise.

-K. Holtz (M.S. thesis). The effect of post-exercise meal composition on insulin action.

Past Publications:

Hasson RE, Freedson PS, Braun B.  Post-exercise insulin action in African-American women.  J Natl Med Assoc. 2006 Nov;98(11):1832-9.

Gerson LS, Barun B.  Effect of high cardiorespiratory fitness and high body fat on insulin resistance.  Med Sci Sports Exerc. 2006 Oct;38(10):1709-15.

Hagobian TA and Braun B.  Interactions between energy surplus and short-term exercise on glucose and insulin responses in healthy people with induced, mild insulin insensitivity.  Metabolism. 2006 Mar;55(3):402-8.

Black SE, Mitchell E, Freedson PS, Chipkin SR, Braun B. Improved insulin action following short-term exercise training: role of energy and carbohydrate balance. J Appl Physiol. 2005 Aug 4

Braun B, Sharoff CG, Chipkin SR, Beaudoin F. Effects of Insulin Resistance on Substrate Utilization During Exercise in Overweight Women J Appl Physiol. 2004 Sep;97(3):991-7. Epub 2004 May 07.

-Braun B, Friedlander AL, Pollack M, Butterfield GE, Marcus R, Hoffman AR. Five weeks of IGF-I treatment does not alter glucose kinetics or insulin sensitivity during a hyperglycemic clamp in older women Metabolism: Clinical and Experimental (in press)

-Braun B, Zimmermann MB , Kretchmer N.  Relationships between glucose metabolism and thermogenesis, with and without prior exercise, in women with NIDDM. Metabolism: Clinical and Experimental  45:747-52, 1996

-Braun B, Zimmermann MB , Kretchmer N, Spargo RM, Smith RM, Gracey M.  Risk factors for diabetes and cardiovascular disease in young Australian Aborigines: A 5-year follow-up study. Diabetes Care 19:472-79, 1996

-Braun B, Zimmermann MB, Kretchmer N.  Effects of exercise intensity on insulin sensitivity in women with NIDDM.  J Appl Physiol 78: 300-06, 1995 

Sex Hormones and Substrate Use during Exercise:

Currently, there are no ongoing studies related to substrate use during exercise.

Past Publications:

-Braun B, Gerson LS, Hagobian TM, Grow D, Chipkin SR. No Effect of Short-term Testosterone Manipulation on Exercise Substrate Metabolism in Men. J Appl Physiol. 2005 Jun 30; [Epub ahead of print]

-D'Eon TM, Sharoff CG, Chipkin SR, Grow D, Ruby BC, Braun B.  Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women.  Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1046-55.

-D'Eon T, Braun B.  The roles of estrogen and progesterone in regulating carbohydrate and fat utilization at rest and during exercise.  J Womens Health Gend Based Med. 2002 Apr;11(3):225-37.

-Braun B, Horton T. Endocrine regulation of exercise substrate utilization in women compared to men. Exerc Sport Sci Rev. 2001 Oct;29(4):149-54.

-Horton T and Braun B. "Energy Metabolism". Principles of Sex-Based Physiology, VM Miller and M Hay, eds., Elsevier Publishing Co. (in press)

-Braun B, Butterfield G, Dominick S, Zamudio S, McCullough R, Rock P, Moore L.  "Women at Altitude: Changes in carbohydrate metabolism at 4300 meters elevation across the menstrual cycle".  J Appl Physiol 85: 1966-73, 1998.

30 Eastman Lane

Room 3, Energy Metabolism Lab

Phone: 413-545-0331

email: bbraun@excsci.umass.edu